Coexistent Psoriasis and Lupus Erythematosus Treated with Alefacept

Authors: Berthelot, Cindy¹; Nash, Jason²; Duvic, Madeleine³

Source: American Journal of Clinical Dermatology, Volume 8, Number 1, 2007 , pp. 47-50(4)

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Abstract:

Coexistence of psoriasis and subacute cutaneous lupus erythematosus (SCLE) is unusual. Although there have been reports of this occurrence, there have been no reports of this overlap syndrome treated with immunomodulators. We describe a case of coexisting psoriasis and SCLE initially treated with infliximab, and then alefacept. The patient's arthritis flared after the second infusion of infliximab, which was discontinued. During treatment with alefacept, the patient's psoriasis improved markedly without exacerbation of his photosensitive SCLE lesions.

Keywords: Alefacept; Lupus; Psoriasis

Document Type: Research article

Affiliations: 1: 1 Department of Internal Medicine, University of Texas Houston Health Science Center, Houston, Texas, USA 2: 2 Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA 3: 3 Department of Dermatology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

Publication date: 2007-01-01