IngentaConnect Cost Effectiveness of Management of Mild-to-Moderate Atopic Derma...

Authors: Ellis, Charles N.¹; Kahler, Kristijan H.²; Grueger, Jens³; Chang, Jane

Source: American Journal of Clinical Dermatology, Volume 7, Number 2, 2006 , pp. 133-139(7)

Abstract:

Introduction: Atopic dermatitis (AD) has the potential to cause a long-term economic impact on patients, their families, and the healthcare system.

Objective: To determine if 1% pimecrolimus cream is cost-effective in treating mild-to-moderate AD in patients 2–17 years of age.

Methods: Data on the efficacy of AD management with 1% pimecrolimus cream (Elidel^®, Novartis Pharma GmbH, Wehr, Germany) were obtained from a 12-month, randomized, double-blind, multinational, controlled clinical trial comparing pimecrolimus and conventional therapy. Markov modeling was used for the economic model, based on: (i) Investigator's Global Assessment scores assessed at each visit during the clinical trial; (ii) estimated costs for medication and physician visits for each level of disease severity; and (iii) utility values for each level of disease severity. The perspective was that of a third-party payer.

Results: In 2004 US dollars, the incremental cost-effectiveness of 1% pimecrolimus cream was $US38 231 per quality-adjusted life year (QALY) gained compared with conventional therapy. Sensitivity analyses showed a range of $US27 299 to $US63 457 per QALY gained.

Conclusion: With an incremental cost-effectiveness ratio of <$US50 000 per QALY gained, 1% pimecrolimus cream offers a cost-effective therapeutic option in the management of AD.

Keywords: Atopic dermatitis; Pimecrolimus

Document Type: Research article

Affiliations: 1: 1 Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA 2: 2 Health Economics and Outcomes Research, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA 3: 3 Pricing & Health Economics, Novartis Pharma AG, Basel, Switzerland

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Cost Effectiveness of Management of Mild-to-Moderate Atopic Dermatitis with 1% Pimecrolimus Cream in Children and Adolescents 2–17 Years of Age