Authors: Salvatore Santo Signorelli,¹; Fatuzzo, Pasquale²; Rapisarda, Francesco²; Neri, Sergio³; Ferrante, Margherita⁴; Gea Oliveri Conti,⁴; Fallico, Roberto⁴; Luigi Di Pino,¹; Pennisi, Giuseppe¹; Celotta, Gabriella¹; Anzaldi, Massimiliano¹

Source: Drugs & Aging, Volume 23, Number 3, 2006 , pp. 263-270(8)

Publisher: Adis International

Abstract:

Objective: We explored the efficacy of intravenous therapy with propionyl L-carnitine in patients with both peripheral arterial disease (PAD) and chronic renal insufficiency requiring haemodialysis.

Methods: The trial was a randomised, double-blind, placebo-controlled trial. Sixty-four patients on haemodialysis (32 per treatment arm) with chronic renal insufficiency and PAD were assigned to receive either intravenous propionyl L-carnitine 600mg or placebo 3 times weekly for 12 months. The main outcome measures were the ankle/brachial index (ABI), plasma malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) concentrations, and the plasma nitrite/nitrate ratio (NO₂/NO₃); these were measured at baseline and at 6 and 12 months.

Results: Significant increases in ABI were observed in the propionyl L-carnitine group, whereas in the placebo group the reverse trend was seen. In patients treated with propionyl L-carnitine, significant progressive decreases were seen in plasma MDA, 4-HNE and the NO₂/NO₃ ratio from baseline. In the placebo-treated group, only weakly significant or no differences were seen.

Conclusion: Intravenous administration of propionyl L-carnitine to haemodialysis patients with PAD improves both haemodynamic flow and the oxidative profile.

Keywords: Peripheral arterial disorders; Propionyl carnitine

Document Type: Research article

Affiliations: 1: 1 Department of Internal Medicine and Systemic Pathology, Medical Angiology Section, University of Catania, Catania, Italy 2: 2 Department of Internal Medicine and Systemic Pathology, Kidney Disease Section, University of Catania, Catania, Italy 3: 3 Department of Internal Medicine and Systemic Pathology, Internal Medicine Section, University of Catania, Catania, Italy 4: 4 Department of Anatomy, Diagnostic Pathology, Legal Medicine and Public Health Faculty of Medicine, University of Catania, Catania, Italy

Publication date: 2006-01-01

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• By this author: Salvatore Santo Signorelli, ;  Fatuzzo, Pasquale ;  Rapisarda, Francesco ;  Neri, Sergio ;  Ferrante, Margherita ;  Gea Oliveri Conti, ;  Fallico, Roberto ;  Luigi Di Pino, ;  Pennisi, Giuseppe ;  Celotta, Gabriella ;  Anzaldi, Massimiliano

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