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Volume 50, Number 8, 1 August 2011

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Leading Article

In Vivo-In Vitro-In Silico Pharmacokinetic Modelling in Drug Development: Current Status and Future Directions
pp. 483-491(9)
Authors: Pelkonen, Olavi; Turpeinen, Miia; Raunio, Hannu

Review Article

A Reappraisal of Current Dosing Strategies for Intravenous Fosfomycin in Children and Neonates
pp. 493-503(11)
Authors: Traunmüller, Friederike; Popovic, Martin; Konz, Karl-Heinz; Vavken, Patrick; Leithner, Andreas; Joukhadar, Christian

Original Research Articles

Prediction of Human Oral Plasma Concentration-Time Profiles Using Preclinical Data: Comparative Evaluation of Prediction Approaches in Early Pharmaceutical Discovery
pp. 505-517(13)
Authors: >An Van den Bergh,; Sinha, Vikash; Gilissen, Ron; Straetemans, Roel; Wuyts, Koen; Morrison, Denise; Bijnens, Luc; Mackie, Claire

Quantitative Prediction of Cytochrome P450 (CYP) 2D6-Mediated Drug Interactions
pp. 519-530(12)
Authors: Tod, Michel; Goutelle, Sylvain; Clavel-Grabit, Fannie; Nicolas, Grégoire; Charpiat, Bruno

HIV/AIDS Patients Display Lower Relative Bioavailability of Efavirenz than Healthy Subjects
pp. 531-540(10)
Authors: Mukonzo, Jackson K.; Nanzigu, Sarah; Rekić, Dinko; Waako, Paul; Röshammar, Daniel; Ashton, Michael; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni

Randomized, Open-Label, Multicentre Pharmacokinetic Studies of Two Dose Levels of Pantoprazole Granules in Infants and Children Aged 1 Month through <6 Years with Gastro-Oesophageal Reflux Disease
pp. 541-550(10)
Authors: Tammara, Brinda K.; Sullivan, Janice E.; Adcock, Kim G.; Kierkus, Jaroslaw; Giblin, John; Rath, Natalie; Meng, Xu; Maguire, Mary K.; Comer, Gail M.; Ward, Robert M.

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