Pharmacokinetics of Opioids in Liver Disease

Authors: Tegeder I.; Lötsch J.; Geisslinger G.

Source: Clinical Pharmacokinetics, Volume 37, Number 1, July 1999 , pp. 17-40(24)

Publisher: Adis International

Abstract:

The liver is the major site of biotransformation for most opioids. Thus, the disposition of these drugs may be affected in patients with liver insufficiency. The major metabolic pathway for most opioids is oxidation. The exceptions are morphine and buprenorphine, which primarily undergo glucuronidation, and remifentanil, which is cleared by ester hydrolysis.

Oxidation of opioids is reduced in patients with hepatic cirrhosis, resulting in decreased drug clearance [for pethidine (meperidine), dextropropoxyphene, pentazocine, tramadol and alfentanil] and/or increased oral bioavailability caused by a reduced first-pass metabolism (for pethidine, dextropropoxyphene, pentazocine and dihydrocodeine). Although glucuronidation is thought to be less affected in liver cirrhosis, the clearance of morphine was found to be decreased and oral bioavailability increased.

The consequence of reduced drug metabolism is the risk of accumulation in the body, especially with repeated administration. Lower doses or longer administration intervals should be used to remedy this risk. Special risks are known for pethidine, with the potential for the accumulation of norpethidine, a metabolite that can cause seizures, and for dextropropoxyphene, for which several cases of hepatotoxicity have been reported. On the other hand, the analgesic activity of codeine and tilidine depends on transformation into the active metabolites, morphine and nortilidine, respectively. If metabolism is decreased in patients with chronic liver disease, the analgesic action of these drugs may be compromised. Finally, the disposition of a few opioids, such as fentanyl, sufentanil and remifentanil, appears to be unaffected in liver disease.

Keywords: Reviews-on-treatment; Morphine, pharmacokinetics; Dextropropoxyphene, pharmacokinetics; Codeine, pharmacokinetics; Buprenorphine, pharmacokinetics; Pentazocine, pharmacokinetics; Tramadol, pharmacokinetics; Tilidine, pharmacokinetics; Fentanyl, pharmacokinetics; Pethidine, pharmacokinetics; Liver-disorders; Metabolism; Clinical-pharmacokinetics; Bioavailability; Opioids, pharmacokinetics; Pain; Alfentanil, pharmacokinetics; Dihydrocodeine, pharmacokinetics; Remifentanil, pharmacokinetics; Sufentanil, pharmacokinetics

Language: English

Document Type: Review article

Affiliations: 1: Center of Pharmacology, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University of Frankfurt, Frankfurt am Main, Germany *

Publication date: 1999-07-01

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• In this Subject: Pharmacology
• By this author: Tegeder I. ;  Lötsch J. ;  Geisslinger G.

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