Rotigotine Transdermal Patch: A Review of its Use in the Management of Parkinson's Disease

Authors: Baldwin, Claudine M.; Keating, Gillian M.

Source: CNS Drugs, Volume 21, Number 12, 2007 , pp. 1039-1055(17)

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Abstract:

A transdermal patch formulation of the non-ergolinic dopamine agonist rotigotine (Neupro^®) is indicated for use as monotherapy in the treatment of early-stage Parkinson's disease or, in the EU, as an adjunct to levodopa across all disease stages. Transdermal rotigotine is an effective and generally well tolerated addition to the armamentarium for the control of Parkinson's disease, with the once-daily transdermal patch system offering several practical advantages and the possible benefits of avoiding pulsatile dopaminergic stimulation. Transdermal rotigotine was superior to placebo in patients with early-stage and advanced Parkinson's disease, although noninferiority to the oral dopamine agonists ropinirole or pramipexole was not consistently demonstrated. Additional active comparator trials would be of interest. In the meantime, transdermal rotigotine offers a convenient new treatment option for patients with Parkinson's disease.

Keywords: Adis Drug Evaluations; Dopamine receptor agonists; Parkinson's disease; Rotigotine; Transdermal

Document Type: Research article

Affiliations: 1: Wolters Kluwer Health | Adis, Auckland, New Zealand, an editorial office of Wolters Kluwer Health, Conshohocken, Pennsylvania, USA

Publication date: 2007-01-01