Authors: Kwak, Kyunghwa¹; Chung, Hoyun²; Lim, Choonhak³; Han, Changgyu¹; Choi, Gwangwook¹; Lim, Donggun¹; Kim, Sioh¹; Jeon, Younghoon¹

Source: Clinical Drug Investigation, Volume 27, Number 7, 2007 , pp. 493-497(5)

Publisher: Adis International

Abstract:

Objective: Pain on injection is a well known adverse effect of propofol. The purpose of this study was to compare the analgesic effect of a lidocaine (lignocaine)/remifentanil combination compared with either lidocaine alone or remifentanil alone during propofol injection for induction of anaesthesia.

Methods: In a randomised, double-blind, prospective trial, 129 patients were allocated to one of three groups (each n = 43) receiving lidocaine 20mg, remifentanil 0.3 μg/kg or lidocaine 20mg plus remifentanil 0.3 μg/kg as pretreatment, followed by injection of 5mL of 1% propofol. Pain severity was evaluated on a four-point scale.

Results: Two patients (4.7%) complained of pain in the lidocaine plus remifentanil group compared with 15 (35.7%) in the lidocaine alone group and 18 (42.9%) in the remifentanil alone group (p < 0.001). There was no significant difference in the incidence of injection pain between the lidocaine alone and remifentanil alone groups (p = 0.21).

Conclusion: Pretreatment with a combination of lidocaine and remifentanil is more effective than either pretreatment alone in reducing pain on injection of propofol.

Keywords: Injection site pain; Lidocaine; Remifentanil

Document Type: Research article

Affiliations: 1: 1 Department of Anesthesiology, School of Medicine, Kyungpook National University, Daegu, Korea 2: 2 Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, Korea 3: 3 Department of Anesthesiology and Pain Medicine, Korea University, Seoul, Korea

Publication date: 2007-01-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Kwak, Kyunghwa ;  Chung, Hoyun ;  Lim, Choonhak ;  Han, Changgyu ;  Choi, Gwangwook ;  Lim, Donggun ;  Kim, Sioh ;  Jeon, Younghoon

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers