Pilot Study of the Efficacy and Safety of a Modified-Release Magnesium 250mg Tablet (Sincromag^®) for the Treatment of Premenstrual Syndrome

Authors: Quaranta, S.¹; Buscaglia, M.A.¹; Meroni, M.G.²; Colombo, E.²; Cella, S.³

Source: Clinical Drug Investigation, Volume 27, Number 1, 2007 , pp. 51-58(8)

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Abstract:

Background: Magnesium deficiency has been implicated as a possible contributing factor to some symptoms of premenstrual syndrome (PMS) and several studies have reported a lower intracellular magnesium concentration in women with PMS. Thus, it has been suggested that magnesium supplementation may improve certain symptoms in women with PMS.

Objective: This open-label study assessed the efficacy and safety of a patented modified-release magnesium 250mg tablet for improving symptoms in women affected by PMS.

Methods: After a 3-month observational period, women aged 18-45 years with a regular menstrual cycle (from 25-35 days) who were affected by PMS (determined by a score of ≥25 points on a PMS questionnaire) [n = 41] were given the modified-release magnesium tablet over three menstrual cycles, beginning 20 days after the start of their last menstrual period and continuing until the start of their next menstrual period.

Results: PMS symptoms improved during magnesium treatment. After 3 months, the mean total PMS score (primary endpoint), as assessed by the investigator using Moos' Modified Menstrual Distress Questionnaire, was significantly lower than before therapy (p < 0.0001). During the same period, the mean PMS scores, as recorded in patients' diaries (secondary efficacy variables), also showed significant improvements (p < 0.0001 for all subscales). The relative decreases in total PMS scores, as assessed by investigator and patient, were 35.1% and 33.5%, respectively. The magnesium tablet was well tolerated, with vertigo the only treatment-related adverse event reported (one patient).

Conclusions: We concluded that modified-release magnesium was effective in reducing premenstrual symptoms in women with PMS in this preliminary study.

Keywords: Magnesium; Premenstrual syndrome

Document Type: Research article

Affiliations: 1: 1 Unità Operativa Ostetricia e Ginecologia, Azienda Ospedaliera Ospedale San Carlo Borromeo, Milan, Italy 2: 2 Unità Operativa Ostetricia e Ginecologia, Azienda Ospedaliera di Busto Arsizio, Varese, Italy 3: 3 Facoltà di Medicina e Chirurgia Università di Milano, Presso Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Milan, Italy

Publication date: 2007-01-01