Cholelithiasis and Thrombosis of the Central Retinal Vein in a Renal Transplant Recipient Treated with Cyclosporin

Authors: Simic, Petra¹; Gasparovic, Vladimir¹; Skegro, Mate²; Stern-Padovan, Ranka³

Source: Clinical Drug Investigation, Volume 26, Number 6, 2006 , pp. 361-365(5)

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Abstract:

The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients. Cholelithiasis in turn enhances the effects of cyclosporin on increased platelet aggregation.

In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation. Seven years after the transplantation, cholelithiasis, cholecystitis, cholangitis and subsequently secondary chronic biliary sclerosis were detected. Latero-lateral anastomosis between the common bile duct and duodenum was performed during explorative laparotomy and ursodeoxycholic acid treatment was introduced. The possible inter-relationship of the cholestatis, central retinal vein thrombosis and immunosuppression are discussed.

Keywords: Cholelithiasis; Ciclosporin; Thrombosis

Document Type: Case report

Affiliations: 1: 1 Department of Medicine, Clinical Hospital Center Rebro, Zagreb, Croatia 2: 2 Department of Surgery, Clinical Hospital Center Rebro, Zagreb, Croatia 3: 3 Department of Radiology, Clinical Hospital Center Rebro, Zagreb, Croatia

Publication date: 2006-01-01