Authors: Rubio-Guerra A.F.¹; Treviño-Gomezharper C.²; Rodríguez-López L.¹; Vargas-Ayala G.¹; Lozano-Nuevo J.J.¹; Arceo-Navarro A.²

Source: Clinical Drug Investigation, Volume 22, Number 8, 1 August 2002 , pp. 541-546(6)

Publisher: Adis International

Abstract:

Objective: To evaluate the effect of the fixed-dose combination of trandolapril/verapamil on albuminuria and renal function in patients with hypertension and type 2 diabetes mellitus unresponsive to treatment with an angiotensin-converting enzyme (ACE) inhibitor.

Subjects and methods: 30 patients with type 2 diabetes mellitus and hypertension whose hypertension could not be controlled with at least 6 months' treatment with an ACE inhibitor were treated with a combination of trandolapril/ verapamil (2mg/180mg once daily). Patients were evaluated monthly over 6 months for sitting blood pressure (BP), heart rate and plasma glucose. A 24-hour urine albumin and a creatinine clearance examination were done prior to and 6 months after the use of the combination.

Results: All the patients had a decrease in their BP, from a mean of 168 ± 5/ 93 ± 3mm Hg to 135 ± 4/79 ± 5mm Hg (p < 0.001), and in urine albumin from 4564.7 ± 563 mg/day to 2096.9 ± 296 mg/day (p < 0.001). There was no significant change in heart rate or in creatinine clearance.

Conclusions: The trandolapril/verapamil combination effectively reduces high BP and albuminuria in patients with type 2 diabetes mellitus whose hypertension is unresponsive to an ACE inhibitor.

Keywords: Antihypertensives, pharmacodynamics; Blood pressure; Heart rate; Renal function; Verapamil/trandolapril, pharmacodynamics

Document Type: Original article

Affiliations: 1: Hypertension Clinic, Hospital General de Ticomán SSDF (General Hospital of Ticoman), Plan de San Luis S/N Esq., Bandera, Mexico 2: Ticoman Group for Hypertension Research, Plan de San Luis S/N Esq., Bandera, Mexico

Publication date: 2002-08-01

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