Sore Throat Treatment during Pregnancy: A Prospective, Controlled, Pilot Study

Authors: Berkovitch M.1; Greenberg R.1; Gendler L.1; Avgil M.1; Bulkowstein M.1; Sthal B.2; Kessler A.3; Merlob P.2

Source: Clinical Drug Investigation, Volume 22, Number 2, 2002 , pp. 135-139(5)

Publisher: Adis International

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

Objective: To determine whether exposure during pregnancy to two types of lozenges used for treatment of sore throat [Kalgaron (Rafa Laboratories, Jerusalem, Israel) or Strepsils (Boots Healthcare International, Nottingham, UK)] was associated with an increased risk of malformations, spontaneous abortions or decreased birthweight.

Design: Prospective, controlled, observational study.

Study participants: The study group included 54 women who received Kalgaron or Strepsils during the first trimester of pregnancy. The control group included 54 women exposed to non-teratogenic drugs.

Results: The rate of major malformations in the study group (3.84%) did not differ from that of the control group (3.92%) [p = 0.98; relative risk 0.98, 95% confidence interval 0.14 to 6.7]. The rate of minor malformations in the study group (1.92%) did not differ statistically from that of the control group (0%) [p = 0.32]. There were also no statistically significant differences in birthweight, rate of live births and rate of spontaneous abortions among the two groups.

Conclusions: The use of Kalgaron or Strepsils during pregnancy was not associated with an increased risk of malformations, spontaneous abortions or decreased birthweight. However, larger studies are needed to confirm the safety of these medications during pregnancy.

Keywords: Antibacterials, therapeutic use; Pharyngitis, treatment; Pregnancy

Document Type: Original article

Affiliations: 1: Clinical Pharmacology and Toxicology Unit, Assaf Harofeh Medical Center, , Zerifin, Israel 2: Department of Neonatology, Rabin Medical Center, Beilinson Campus, Petah Tikva, affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 3: Otolaryngology Head and Neck Surgery, Assaf Harofeh Medical Center, Zerefin, Israel

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$62.95 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A