Dental Pain: Clinical Evidence with Piroxicam--Cyclodextrin

Author: Desjardins P.J.

Source: Clinical Drug Investigation, Volume 19, Supplement 2, 2000 , pp. 41-46(6)

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Abstract:

Although the analgesic properties of piroxicam in postoperative settings (e.g. post-dental extraction) have been well documented, the relatively slow onset of action of this nonsteroidal anti-inflammatory drug (NSAID) has somewhat limited its usefulness. To counter this disadvantage, piroxicam has been complexed with the cyclic oligosaccharide beta -cyclodextrin, to form piroxicam- beta -cyclodextrin. This new compound enhances the aqueous solubility of piroxicam, increases its rate of absorption, and results in more rapid achievement of therapeutic concentrations than occurs with standard piroxicam. Clinical studies in patients with postoperative dental pain have shown that piroxicam- beta -cyclodextrin is an effective analgesic agent. Furthermore, these studies have shown that the onset of analgesia provided by oral piroxicam- beta -cyclodextrin in this setting is comparable to that of paracetamol and ibuprofen, and possibly more rapid than that of standard piroxicam. Oral piroxicam- beta -cyclodextrin is thus a rapid and effective agent for the relief of postoperative dental pain.

Keywords: Dental pain, treatment; Ibuprofen, therapeutic use; Meclofenamic acid, therapeutic use; Nonsteroidal antiinflammatories, therapeutic use; Paracetamol, therapeutic use; Piroxicam, therapeutic use; Piroxicam beta cyclodextrin, therapeutic use

Language: English

Document Type: Review article

Affiliations: 1: Clinical Site Operations, Analgesia and Psychiatric Research, Scirex Corporation, Austin, Texasand University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark, New Jersey, USA *

Publication date: 2000-01-01