@article {Dawood:2000:1173-2563:37,
	author = "Dawood M.",
	title = "Dysmenorrhoea: Clinical Evidence with Piroxicam-beta-Cyclodextrin",
	journal = "Clinical Drug Investigation",
	volume = "19",
	year = "2000",
	abstract = "<P>Primary dysmenorrhoea can be readily relieved with nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs inhibit prostaglandin synthetase, reducing the level of prostanoids in the uterus and the uterine contractions that cause the painful cramps. Piroxicam-<IMG SRC="/iso-ents/isogrk32/beta-s.gif" ALT="beta">-cyclodextrin is rapidly absorbed and quickly reaches peak blood concentrations. Four published clinical studies have evaluated piroxicam-<IMG SRC="/iso-ents/isogrk32/beta-s.gif" ALT="beta">-cyclodextrin for relief of primary dysmenorrhoea. Piroxicam-<IMG SRC="/iso-ents/isogrk32/beta-s.gif" ALT="beta">-cyclodextrin 20mg once daily was significantly more effective than placebo in relief of dysmenorrhoea, was better than ketoprofen in relieving the abdominal pain of dysmenorrhoea, and had a quicker onset and longer duration of relief than naproxen. Both investigators and patients rated a greater preference for piroxicam-<IMG SRC="/iso-ents/isogrk32/beta-s.gif" ALT="beta">-cyclodextrin over the comparator medications. The tolerability of piroxicam-<IMG SRC="/iso-ents/isogrk32/beta-s.gif" ALT="beta">-cyclodextrin in the treatment of dysmenorrhoea was good, with a very low incidence of adverse effects.</P>",
	pages = "37-40(4)",
	url = "http://www.ingentaconnect.com/content/adis/cdi/2000/00000019/A00200s2/art00006"
}