Clinical Pharmacology of Piroxicam--Cyclodextrin: Implications for Innovative Patient Care

Author: McEwen J.

Source: Clinical Drug Investigation, Volume 19, Supplement 2, 2000 , pp. 27-31(5)

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Abstract:

The potential advantages of the piroxicam- beta -cyclodextrin complex include more rapid absorption, more rapid onset of analgesia and improved gastrointestinal tolerability. These have been critically evaluated with reference to published work. In association with improved solubilisation, more rapid absorption of piroxicam has been clearly demonstrated, while its intrinsically long terminal half-life is maintained. There are several reports of improved gastrointestinal tolerability in comparison with conventional piroxicam: the clearest evidence for this has come from studies in healthy individuals, and it has not yet been established whether piroxicam- beta -cyclodextrin causes less gastrointestinal haemorrhage than conventional piroxicam in patients treated in routine clinical practice. Although not totally inert, the carrier beta -cyclodextrin appears to be safe for oral clinical use. Piroxicam- beta -cyclodextrin is clearly an effective analgesic with a rapid onset of effect, representing a promising approach towards more effective and safe delivery of NSAIDs.

Keywords: Nonsteroidal antiinflammatories, pharmacodynamics; Piroxicam beta cyclodextrin, pharmacodynamics

Language: English

Document Type: Review article

Affiliations: 1: DDS Medicines Research Limited, Ninewells Hospital and Medical School, Dundee, Scotland *

Publication date: 2000-01-01