IngentaConnect CYP3A5 Genotype is Associated with Diagnosis of Hypertension in E...

Authors: Kivistö, Kari T.¹; Niemi, Mikko; Schaeffeler, Elke¹; Pitkälä, Kaisu²; Tilvis, Reijo²; Fromm, Martin F.; Schwab, Matthias¹; Lang, Florian³; Eichelbaum, Michel¹; Strandberg, Timo²

Source: American Journal of PharmacoGenomics, Volume 5, Number 3, 2005 , pp. 191-195(5)

Publisher: Adis International

Abstract:

Objective: The aim of this study was to address the presently controversial question of whether cytochrome P450 (CYP) 3A5 polymorphism is associated with hypertension.

Method: We studied 373 elderly (age

75 years) Finnish (Caucasian) patients from the ongoing DEBATE (Drugs and Evidence Based Medicine in the Elderly) trial. The patients were classified into those with a history of hypertension (n = 229) and those without a history of hypertension (n = 144) on the basis of a detailed questionnaire on each patient’s medical history and an interview. The patients were genotyped for the CYP3A5 6986A/G single nucleotide polymorphism (SNP) [CYP3A5*1/*3 alleles].

Results: The proportion of individuals with the CYP3A5*1/*3 genotype, i.e. CYP3A5 expressors, was significantly higher among patients with a diagnosis of hypertension than among patients without (18.3% vs 9.0%, p = 0.016). The corresponding odds ratio was 2.26 (95% CI 1.17, 4.38). The allele and genotype frequencies for the two control SNPs, ABCB1 (MDR1) 3435C/T and SLCO1B1 521T/C, did not differ between the two groups.

Conclusion: This work lends support to the theory that the polymorphic CYP3A5 enzyme may be involved in regulation of blood pressure. The possible role of CYP3A5 as a genetic contributor to hypertension susceptibility warrants further study.

Keywords: Hypertension; Genetic polymorphism; Cytochrome P450; Elderly

Document Type: Research article

Affiliations: 1: 1 Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany 2: 3 Department of Medicine, Geriatric Clinic, University of Helsinki, Helsinki, Finland 3: 5 Department of Physiology, University of Tübingen, Tübingen, Germany

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CYP3A5 Genotype is Associated with Diagnosis of Hypertension in Elderly Patients: Data from the DEBATE Study