GOAT: An R Tool for Analysing Gene Ontology™ Term Enrichment

Authors: Xu, Qikai; Shaulsky, Gad

Source: Applied Bioinformatics, Volume 4, Number 4, 2005 , pp. 281-283(3)

Publisher: Adis International

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Abstract:

Understanding the composition of gene lists that result from high-throughput experiments requires elaborate processing of gene annotation lists. In this article we present GOAT (Gene Ontology Analysis Tool), a tool based on the statistical software ‘R’ for analysing Gene Ontology™ (GO) term enrichment in gene lists. Given a gene list, GOAT calculates the enrichment and statistical significance of every GO term and generates graphical presentations of significantly enriched terms. GOAT works for any organism with a genome-scale GO annotation and allows easy updates of ontologies and annotations.

Availability: GOAT is freely available from http://dictygenome.org/software/GOAT/

Contact: Gad Shaulsky (gadi@bcm.tmc.edu)

Keywords: Bioinformatics; Computers; Genomics

Document Type: Research article

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