The effect of using a powered toothbrush on MCP-1 and RANTES levels in patients with Gingivitis

Authors: Paquette, Linda L; Wilder, Rebecca S; Barros, Silvana P; Jared, Heather L

Source: Journal of Dental Hygiene, 1 October 2008, vol. 82, no. 5, pp. 53-53(1)

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Abstract:

The purpose of this pilot study was to investigate if a powered toothbrush significantly reduced the concentration of MCP-1 and RANTES over time in a gingivitis group when compared to a manual toothbrush. MCP-1 and RANTES are pro-inflammatory cytokines that are expressed in gingival crevicular fluid of patients with gingival inflammation. This study looked at the levels of these cytokines as indicators for a reduction in the host inflammatory and immune response.



Twenty gingivitis patients, 18-65 years of age with pocket depths ≤6mm and a minimum of 10% bleeding upon probing were enrolled in this IRB approved pilot study. Participants randomly assigned to one of two treatment arms, the powered toothbrush or the manual toothbrush, were seen for five study visits and gingival crevicular fluid samples were collected at baseline and 24 weeks post therapy.



No statistically significant differences were found between groups at baseline in clinical measurements, GCF levels of MCP-1 and RANTES and demographics, with the exception of race (p=0.01). When comparing the treatment group to the control group, no statistical differences were found between the GCF levels for MCP-1 and RANTES at baseline and 24 weeks post treatment (p=0.20 and p=0.19, respectively).



Within the limitations of this study, a trend in the reduction of the local indicators of inflammatory response was seen; however, the differences were not statistically significant. Further investigation needs to be conducted, with a larger sample size, to evaluate the effect of a powered toothbrush on the inflammatory mediators, MCP-1 and RANTES. This pilot study was nested within a larger, ongoing study of 84 participants.

Document Type: Abstract

Affiliations: University of North Carolina at Chapel Hill

Publication date: October 1, 2008

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