The Effect of Periodontal Therapy on TNF-α, IL-6 and Metabolic Control in Type 2 Diabetics
Authors: Talbert, Jennifer; Elter, John; Jared, Heather L; Offenbacher, Steve; Southerland, Janet; Wilder, Rebecca S
Source: Journal of Dental Hygiene, Volume 80, Number 2, Spring 2006 , pp. 7-7(1)
Publisher: American Dental Hygienists' Association
Purpose. This pilot study investigated if scaling and root planing (S&RP) was an effective intervention in reducing levels of inflammatory markers TNF-α and IL-6 in a type 2 diabetic population
Methods. Twenty-five patients with type 2 diabetes, 18-64 years of age were enrolled having 4 or more sites with pocket depths ≥ 5mm and 2 or more sites with attachment loss ≥ 3mm. Participants received S&RP following collection of gingival crevicular fluid and serum which were analyzed for TNF-α and IL-6. After 3 months post-treatment levels were collected. Serum pre-and post-treatment levels were analyzed using a paired t test at a significance level of p≤ 0.05. Mean TNF-α was 1.7pg/ml at baseline and post-treatment was 4.0pg/ml. Mean IL-6 was 2.8pg/ml at baseline and post-treatment 6.0pg/ml.
Results. Both mean TNF-α and IL-6 were increased following S&RP ; however, the observed increases were not statistically significant. While participants improved on periodontal measures following therapy, systemic measures of inflammation (TNF-α and IL-6) did not show the hypothesized reductions.
Conclusion. Further studies are needed to determine effectiveness of S&RP on inflammatory mediators in a population with type 2 diabetes.
Document Type: Research Article
Affiliations: Clinical Instructor, UNC School of Dentistry.
Publication date: 2006-03-01