IngentaConnect Effect on growth of long-term treatment with intranasal triamcino...

Authors: Skoner, David P.; Gentile, Deborah A.; Doyle, William J.

Source: Annals of Allergy, Asthma and Immunology, Volume 101, Number 4, October 2008 , pp. 431-436(6)

Publisher: American College of Allergy, Asthma, & Immunology

Abstract:

Background: Guidelines recommend treatment with intranasal corticosteroids for patients with allergic rhinitis (AR), but concerns remain about possible adverse effects.

Objective: To present the 1- and 2-year growth results for children with AR treated with triamcinolone acetonide aqueous nasal spray.

Methods: Thirty-nine children (aged 6.1-14.3 years at study entry) were treated with triamcinolone acetonide aqueous for 1 year, and a subset of 30 children completed a second year of treatment. The dose was physician titered to achieve control over AR symptoms. For each child, statural heights at baseline and at the 1- and 2-year (where available) visits, together with growth rates, were measured and were compared with predicted values.

Results: There were no significant differences between measured and predicted heights at the 1- and 2-year visits. The mean (SD) measured − predicted difference was 0.3 (2.2) cm (95% confidence interval, −0.4 to 1.0 cm) at the 1-year visit and 0.5 (3.0) cm (95% confidence interval, −0.6 to 1.6 cm) at the 2-year visit. Mean differences in measured and predicted growth rates were nonsignificant at the 1- and 2-year visits.

Conclusions: Triamcinolone acetonide aqueous titered to control AR symptoms and given for 1 or 2 years had no significant effect on statural growth in children with AR.

Effect on growth of long-term treatment with intranasal triamcinolone acetonide aqueous in children with allergic rhinitis