Authors: White, Andrew A.; Hope, Andrew P.; Stevenson, Donald D.
Source: Annals of Allergy, Asthma and Immunology, Volume 97, Number 4, October 2006 , pp. 446-448(3)
Publisher: American College of Allergy, Asthma, & Immunology
Abstract:
Background: Aspirin desensitization is a useful therapy in patients with aspirin-exacerbated respiratory disease. Objective: To describe the clinical course of a man with aspirin-exacerbated respiratory disease who was unable to be desensitized to oral aspirin. Methods: A standard aspirin desensitization protocol was used to achieve a maximum dose of 650 mg of oral aspirin. The patient initially tolerated this dose of aspirin. Results: Within days of desensitization, the patient began to react to 650 mg of aspirin. Monitored challenge with this dose of aspirin led to marked decrease in forced expiratory volume in 1 second and pronounced nasal and ocular symptoms. Conclusions: We present a patient with classic aspirin-exacerbated respiratory disease, who despite undergoing a standard aspirin desensitization protocol was unable to maintain his desensitized state.Document Type: Case report
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