Failure to maintain an aspirin-desensitized state in a patient with aspirin-exacerbated respiratory disease

Authors: White, Andrew A.; Hope, Andrew P.; Stevenson, Donald D.

Source: Annals of Allergy, Asthma and Immunology, Volume 97, Number 4, October 2006 , pp. 446-448(3)

Publisher: American College of Allergy, Asthma, & Immunology

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Abstract:

Background: Aspirin desensitization is a useful therapy in patients with aspirin-exacerbated respiratory disease.

Objective: To describe the clinical course of a man with aspirin-exacerbated respiratory disease who was unable to be desensitized to oral aspirin.

Methods: A standard aspirin desensitization protocol was used to achieve a maximum dose of 650 mg of oral aspirin. The patient initially tolerated this dose of aspirin.

Results: Within days of desensitization, the patient began to react to 650 mg of aspirin. Monitored challenge with this dose of aspirin led to marked decrease in forced expiratory volume in 1 second and pronounced nasal and ocular symptoms.

Conclusions: We present a patient with classic aspirin-exacerbated respiratory disease, who despite undergoing a standard aspirin desensitization protocol was unable to maintain his desensitized state.

Document Type: Case report

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