@article {Pearlman:September 2006:1081-1206:382,
	author = "Pearlman, David",
	author = "Milgrom, Henry",
	author = "Till, Denise",
	author = "Ziehmer, Barbara",
	title = "Effect of formoterol fumarate treatment on exercise-induced bronchoconstriction in children",
	journal = "Annals of Allergy, Asthma and Immunology",
	volume = "97",
	year = "September 2006",
	abstract = "Background: Exercise-induced bronchoconstriction (EIB) is common, particularly in children.<P></P> <P></P> Objectives: To compare the protective effect of single doses of formoterol fumarate via Aerolizer with placebo and albuterol in children with EIB.<P></P> <P></P> Methods: In this randomized, double-blind, double-dummy, crossover trial, 23 children (aged 4-11 years) received formoterol, 12 or 24 &#956;g; albuterol, 180 &#956;g; or placebo at 4 separate visits. Protection against EIB was evaluated as the maximum percentage decrease in forced expiratory volume in 1 second (FEV<SUB>1</SUB>) from the preexercise value after exercise challenge tests (6-minute treadmill) conducted 15 minutes and 4, 8, and 12 hours after administration of the dose.<P></P> <P></P> Results: The maximum percentage decrease in FEV<SUB>1</SUB> after the 4-hour exercise test (primary efficacy variable) was significantly less for formoterol, 12 and 24 &#956;g, vs placebo (<I>P</I> &#60; .001 for both) or albuterol (<I>P</I> &#61; .016 and .010, respectively); albuterol was not significantly different from placebo. Formoterol, 12 and 24 &#956;g, differed from placebo at 8 hours (<I>P</I> &#61; .002 and .001, respectively), with a smaller difference between albuterol and placebo (<I>P</I> &#61; .045). Rescue medication use and a high dropout rate may have biased treatment differences at later time points. Protection against EIB (&#60;20% maximum decrease in FEV<SUB>1</SUB>) across all time points was observed for 17 (77%) of 22 and 17 (74%) of 23 children with formoterol, 12 and 24 &#956;g, respectively, compared with 8 (35%) of 23 with albuterol and 6 (27%) of 22 with placebo.<P></P> <P></P> Conclusions: Single doses of formoterol, 12 or 24 &#956;g, are effective in protecting against EIB in children, affording a statistically significantly greater protective effect than placebo or albuterol.",
	pages = "382-388(7)",
	url = "http://www.ingentaconnect.com/content/acaai/aaai/2006/00000097/00000003/art00020"
}