A report of a rare immediate reaction after ingestion of acetaminophen

Authors: Grant, Julie A.; Weiler, John M.

Source: Annals of Allergy, Asthma and Immunology, Volume 87, Number 3, September 2001 , pp. 227-229(3)

Publisher: American College of Allergy, Asthma, & Immunology

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Abstract:

Background: Acetaminophen hypersensitivity is rare and, when seen, is usually in association with sensitivity to nonsteroidal anti-inflammatory drugs.

Methods: This is a case report of an immediate reaction to acetaminophen, confirmed by a drug challenge, in a subject who tolerated ibuprofen.

Results: After an oral challenge with 50 mg of acetaminophen, the subject had generalized pruritus, urticaria, and dyspnea.

Conclusions: This patient demonstrates a rare but potentially severe reaction to acetaminophen that may occur in patients who are not otherwise sensitive to other nonsteroidal anti-inflammatory drugs.

Document Type: Original article

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