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Open Access Fibromyalgia, Thyroid Dysfunction and Treatment Modalities

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Fibromyalgia is a debilitating condition presenting with symptoms of chronic muscular pain, fatigue, insomnia and cognitive dysfunction among other symptoms, which lead to a diminished quality of life. Although the exact pathogenesis and underlying mechanisms which lead to clinical manifestation are unknown, there is a growing line of evidence suggesting an association between fibromyalgia and thyroid dysfunction. Numerous studies have reported that patients with fibromyalgia have a high incidence of hypothyroidism. Further, thyroid autoimmunity has also been associated with fibromyalgia symptom severity. Circulating thyroid hormones do not provide an accurate status of thyroid function in patients with fibromyalgia, rather intracellular thyroid hormone levels are more relevant. Low levels of intracellular hormones may result from mitochondrial dysfunction as active transport of hormones across cellular membranes is required. It is well known that mitochondrial dysfunction is associated with fibromyalgia. In order to correct thyroid dysfunction and manage symptoms presenting in fibromyalgia patients, a multi-disciplinary approach should be taken incorporating dietary supplements, nutraceuticals, dietary changes and complementary alternative therapies.
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Keywords: Fibromyalgia; Thyroid antibodies; Thyroid dysfunction; Thyroid hormones

Document Type: Research Article

Publication date: 01 October 2013

More about this publication?
  • JRM is a peer-reviewed medical journal published annually by AARM. It publishes original research, reviews, and editorials that contribute to the understanding of nutritional and botanical influence on underlying mechanisms of chronic illness. The journal was established by Michaël Friedman, ND as the founding editor. The journal's current editor-in-chief is Liz Sutherland, ND of National University of Natural Medicine.
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