Maternal Transmission of Mutans Streptococci in Severe-Early Childhood Caries

Authors: Mitchell, Stephen C.; Ruby, John D.; Moser, Stephen; Momeni, Stephanie; Smith, Anita; Osgood, Robert; Litaker, Mark; Childers, Noel

Source: Pediatric Dentistry, Volume 31, Number 3, May/June 2009 , pp. 193-201(9)

Publisher: American Academy of Pediatric Dentistry

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Abstract:

Purpose: This study utilized multiple genetic analyses to detect evidence of maternal MS acquisition in children with S-ECC. Methods: Twenty-seven mother/child pairs were selected from children with S-ECC preceding dental rehabilitation under general anesthesia. Plaque samples were collected from the mother, child, and the child's carious lesion. Arbitrarily primed-polymerase chain reaction (AP-PCR) genotyped 6-8 MS isolates from each plaque sample, and unique genotypes were identified. Representative MS isolates with unique genotypes were characterized by pulsed-field gel electrophoresis (PFGE). Cluster analysis using the Dice band-based similarity coefficient was used to generate dendrograms from gel banding patterns. A Dice coefficient >70% indicated similarity or match among PFGE genotypes. Results: In 26% (7/27) of mother/child pairs, all of the child's isolates matched the mother. In 15% (4/27), some of the child's genotypes matched the mother, and in 59% (16/27), no isolates matched the mother. Maternal transmission was a mode of MS acquisition in 41% (11/27) of mother/child pairs, while acquisition from non-maternal sources occurred in 74% (20/27). Conclusions: MS genotypes that did not match maternal strains were identified in the majority of children (74%) within this S-ECC population. Evidence of maternal transmission was detected in 41% of mother/child pairs.

Keywords: CARIOLOGY; INFANT ORAL HEALTH/EARLY CHILDHOOD CARIES; MICROBIOLOGY; MUTANS STREPTOCOCCI; TRANSMISSION

Document Type: Research article

Publication date: 2009-05-01

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Pediatric Dentistry is the official publication of the American Academy of Pediatric Dentistry, the American Board of Pediatric Dentistry and the College of Diplomates of the American Board of Pediatric Dentistry. It is published bi-monthly and is internationally recognized as the leading journal in the area of pediatric dentistry. The journal promotes the practice, education and research specifically related to the specialty of pediatric dentistry. This peer-reviewed journal features scientific articles, case reports and abstracts of current pediatric dental research.
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Maternal Transmission of Mutans Streptococci in Severe-Early Childhood Caries

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