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Porphyromonas Gingivalis and IgG1 and IgG2 Subclass Antibodies in Patients with Juvenile Idiopathic Arthritis

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Purpose: The purpose of this study was to evaluate the periodontal status and the presence and concentration of Porphyromonas gingivalis (P. gingivalis) and immunoglobulin G (IgG) subclass against P. gingivalis in juvenile idiopathic arthritis (JIA) and its association with rheumatic clinical activity parameters.

Methods: Rheumatologic conditions and periodontal status were clinically assessed in 51 patients with JIA. P. gingivalis, IgG1 and IgG2, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs), and human leukocyte antigen B27 were also evaluated.

Results: Periodontitis was observed in 21.5 percent of the patients, 23.5 percent of whom were positive for P. gingivalis, which was associated with enthesitis-related arthritis (P<0.035). IgG1 against P gingivalis was associated with RF autoantibodies (P=0.05), and all patients positive for ACPAs had higher anti-P gingivalis IgG1 levels. A significant correlation was found between the presence of limited joint mobility and the plaque index in polyarticular JIA (r=0.55, P=0.028).

Conclusions: An association between IgG and rheumatic disease activity markers in JIA was evident. It is important to investigate the familiar periodontal status and clinical course in JIA, especially in enthesitis-related arthritis.
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Keywords: ANTI-CITRULLINATED PROTEIN ANTIBODIES; JUVENILE IDIOPATHIC RHEUMATOID ARTHRITIS; PERIODONTAL DISEASE; PORPHYROMONAS GINGIVALIS

Document Type: Research Article

Affiliations: 1: Associate professor, in the Unit of Oral Basic Investigation, School of Dentistry, at the Universidad El Bosque, in Bogotá, Bacteriologist, Department of Rheumatology and Immunology, Hospital Militar Central, in Bogotá, Colombia;, Email: [email protected] 2: Assistant professor, Staff pediatrician, Department of Pediatrics, School of Medicine, at the Universidad El Bosque, in Bogotá, Colombia 3: Fellow in Rheumatology, Pediatric Postgraduate Program, School of Medicine, at the Universidad El Bosque, in Bogotá, Colombia 4: Associate professor, in the Unit of Oral Basic Investigation, School of Dentistry, at the Universidad El Bosque, in Bogotá, Colombia 5: Assistant professor, in the Unit of Oral Basic Investigation, School of Dentistry, at the Universidad El Bosque, in Bogotá, Colombia 6: Staff dentist, in the Unit of Oral Basic Investigation, School of Dentistry, at the Universidad El Bosque, in Bogotá, Colombia 7: Assistant professor, School of Medicine, at the Universidad El Bosque, in Bogotá, Colombia 8: Professor, in the Unit of Oral Basic Investigation, School of Dentistry, at the Universidad El Bosque, in Bogotá, Colombia

Publication date: 01 May 2017

More about this publication?
  • Acquired after the merger between the American Society of Dentistry for Children and the American Academy of Pediatric Dentistry in 2002, the Journal of Dentistry for Children (JDC) is an internationally renowned journal whose publishing dates back to 1934. Published three times a year, JDC promotes the practice, education and research specifically related to the specialty of pediatric dentistry. It covers a wide range of topics related to the clinical care of children, from clinical techniques of daily importance to the practitioner, to studies on child behavior and growth and development. JDC also provides information on the physical, psychological and emotional conditions of children as they relate to and affect their dental health.
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