Using Identity-by-descent Information in Affected Sib Pairs to Increase the Efficiency of Genetic Association Studies

Authors: Wicks, Jacqueline¹; Treloar, Susan A.¹; Martin, Nicholas G.¹

Source: Twin Research, Volume 7, Number 2, 1 April 2004 , pp. 211-216(6)

Publisher: Australian Academic Press

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Abstract:

The aim of this study was to determine whether identity-by-descent (IBD) information for affected sib pairs (ASPs) can be used to select a sample of cases for a genetic case-control study which will provide more power for detecting association with loci in a known linkage region. By modeling the expected frequency of the disease allele in ASPs showing IBD sharing of 0, 1, or 2 alleles, and considering additive, recessive, and dominant disease models, we show that cases selected from IBD 2 families are best for this purpose, followed by those selected from IBD 1 families; least useful are cases selected from IBD 0 families.

Document Type: Research article

DOI: 10.1375/136905204323016195

Affiliations: 1: Queensland Institute of Medical Research, Brisbane, Australia

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