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Open Access Natural Infection of Burkholderia pseudomallei in an Imported Pigtail Macaque (Macaca nemestrina) and Management of the Exposed Colony

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Identification of the select agent Burkholderia pseudomallei in macaques imported into the United States is rare. A purpose-bred, 4.5-y-old pigtail macaque (Macaca nemestrina) imported from Southeast Asia was received from a commercial vendor at our facility in March 2012. After the initial acclimation period of 5 to 7 d, physical examination of the macaque revealed a subcutaneous abscess that surrounded the right stifle joint. The wound was treated and resolved over 3 mo. In August 2012, 2 mo after the stifle joint wound resolved, the macaque exhibited neurologic clinical signs. Postmortem microbiologic analysis revealed that the macaque was infected with B. pseudomallei. This case report describes the clinical evaluation of a B. pseudomallei-infected macaque, management and care of the potentially exposed colony of animals, and protocols established for the animal care staff that worked with the infected macaque and potentially exposed colony. This article also provides relevant information on addressing matters related to regulatory issues and risk management of potentially exposed animals and animal care staff.

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Document Type: Research Article

Affiliations: 1: National Center for Emerging and Zoonotic Infectious Diseases, Division of Scientific Resources, Animal Resources Branch, Atlanta, Georgia, Center for Comparative Medicine and Surgery, Icahn School of Medicine at Mt Sinai, New York, New York 2: National Center for Emerging and Zoonotic Infectious Diseases, Division of Scientific Resources, Animal Resources Branch, Atlanta, Georgia 3: National Center for Emerging and Zoonotic Infectious Diseases, Division of Scientific Resources, Animal Resources Branch, Laboratory Animal Medicine Residency Program, Atlanta, Georgia 4: National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Bacterial Special Pathogens Branch, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia

Publication date: 2013-12-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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