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Open Access Cerebral Amyloid Angiopathy in an Aged Sooty Mangabey (Cercocebus atys)

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Abstract:

A 26-y-old male sooty mangabey (Cercocebus atys) was found at necropsy to have a moderate degree of cerebral amyloid β (Aβ) angiopathy in superficial and parenchymal blood vessels of the brain. Senile (Aβ) plaques were absent, as were neurofibrillary tangles and other signs of neurodegeneration. Affected blood vessels were arterial, capillary, and, less frequently, venous in nature. Histologically, the Aβ40 isoform was more prevalent than was Aβ42. As in humans but unlike in squirrel monkeys, the density of lesions in this mangabey increased along a rostral-to-caudal gradient. Therefore mangabeys appear to conform to the general tendency of nonhuman primates by developing cerebral Aβ angiopathy in the absence of other indices of Alzheimer-type neuropathology.

Document Type: Research Article

Affiliations: 1: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 2: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, Department of Neurology, Emory University, Atlanta, Georgia 3: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, Department of Psychology, University of Hawaii at Hilo, Hilo, Hawaii;, Email: eheuer@hawaii.edu

Publication date: December 1, 2013

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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