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Open Access Multiple Complex Congenital Malformations in a Rabbit Kit (Oryctolagus cuniculi)

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Congenital malformations may occur during early embryogenesis in cases of genetic abnormalities or various environmental factors. Affected subjects most often have only one or 2 abnormalities; subjects rarely have several unrelated congenital defects. Here we describe a case of a stillborn New Zealand white rabbit with multiple complex congenital malformations, including synophthalmia, holoprosencephaly, gastroschisis, and a supernumerary hindlimb, among other anomalies. There was no historical exposure to teratogens or other known environmental causes. Although not confirmed, this case was most likely a rare spontaneous genetic event.

Document Type: Case Report

Affiliations: 1: Department of Comparative Medicine, Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA 2: Departments of Pathology, Neurosurgery, Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA 3: Departments of Comparative Medicine, Pathology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA. tcooper@hmc.psu.edu

Publication date: August 1, 2013

More about this publication?
  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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