Skip to main content

Open Access Anaplastic Renal Carcinoma Expressing SV40 T Antigen in a Female TRAMP Mouse

Download Article:
 Download
(PDF 159.7 kb)
 

Abstract:

An 8-mo-old female transgenic adenocarcinoma of the mouse prostate (C57BL/6-Tg(TRAMP)8247Ng/J) mouse presented with abdominal distention, lethargy, and serosanguineous vaginal discharge. A large primary renal tumor with metastases to lung and liver was present at necropsy. The tumor was composed of poorly differentiated and crowded epithelial cells forming ducts, acini, and cribriform patterns, with comedonecrosis and frequent bizarre mitoses. Immunohistochemistry revealed that neoplastic cells expressed nuclear SV40 T antigen, confirming aberrant expression of the transgene. In addition, cells were positive for pancytokeratin and negative for synaptophysin and estrogen and progesterone receptors. This report details the first transgene-induced tumor in a female TRAMP mouse.

Document Type: Case Report

Affiliations: 1: Department of Comparative Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA 2: Department of Comparative Medicine, Penn State College of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA 3: Department of Pathology, Penn State College of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA 4: Department of Microbiology and Immunology, Penn State College of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA 5: Department of Comparative Medicine, Penn State College of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA; Department of Pathology, Penn State College of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA. tcooper@hmc.psu.edu

Publication date: August 1, 2013

More about this publication?
  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

    Attention Members: To access the full text of the articles, be sure you are logged in to the AALAS website.

    Attention: please note, due to a temporary technical problem, reference linking within the content is not available at this time

  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Membership Information
  • Information for Advertisers
  • For issues prior to 1998
  • Institutional Subscription Activation
  • Ingenta Connect is not responsible for the content or availability of external websites
aalas/cm/2013/00000063/00000004/art00006
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more