Anaplastic Renal Carcinoma Expressing SV40 T Antigen in a Female TRAMP Mouse
Abstract:An 8-mo-old female transgenic adenocarcinoma of the mouse prostate (C57BL/6-Tg(TRAMP)8247Ng/J) mouse presented with abdominal distention, lethargy, and serosanguineous vaginal discharge. A large primary renal tumor with metastases to lung and liver was present at necropsy. The tumor was composed of poorly differentiated and crowded epithelial cells forming ducts, acini, and cribriform patterns, with comedonecrosis and frequent bizarre mitoses. Immunohistochemistry revealed that neoplastic cells expressed nuclear SV40 T antigen, confirming aberrant expression of the transgene. In addition, cells were positive for pancytokeratin and negative for synaptophysin and estrogen and progesterone receptors. This report details the first transgene-induced tumor in a female TRAMP mouse.
Document Type: Case Report
Affiliations: 1: Department of Comparative Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA 2: Department of Comparative Medicine, Penn State College of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA 3: Department of Pathology, Penn State College of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA 4: Department of Microbiology and Immunology, Penn State College of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA 5: Department of Comparative Medicine, Penn State College of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA; Department of Pathology, Penn State College of Medicine, Hershey Medical Center, Hershey, Pennsylvania, USA. email@example.com
Publication date: August 1, 2013
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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