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Parenchymal Signal Intensity in 3-T Body MRI of Dogs with Hematopoietic Neoplasia

Authors: Feeney, Daniel A1; Sharkey, Leslie C2; Steward, Susan M3; Bahr, Katherine L4; Henson, Michael S2; Ito, Daisuke2; O'Brien, Timothy D5; Jessen, Carl R6; Husbands, Brian D6; Borgatti, Antonella7; Modiano, Jaime F2

Source: Comparative Medicine, Volume 63, Number 2, April 2013 , pp. 174-182(9)

Publisher: American Association for Laboratory Animal Science

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Abstract:

We performed a preliminary study involving 10 dogs to assess the applicability of body MRI for staging of canine diffuse hematopoietic neoplasia. T1-weighted (before and after intravenous gadolinium), T2-weighted, in-phase, out-of-phase, and short tau inversion recovery pulse sequences were used. By using digital region of interest (ROI) and visual comparison techniques, relative parenchymal organ (medial iliac lymph nodes, liver, spleen, kidney cortex, and kidney medulla) signal intensity was quantified as less than, equal to, or greater than that of skeletal muscle in 2 clinically normal young adult dogs and 10 dogs affected with either B-cell lymphoma (n = 7) or myelodysplastic syndrome (n = 3). Falciform fat and urinary bladder were evaluated to provide additional perspective regarding signal intensity from the pulse sequences. Dogs with nonfocal disease could be distinguished from normal dogs according to both the visual and ROI signal-intensity relationships. In normal dogs, liver signal intensity on the T2-weighted sequence was greater than that of skeletal muscle by using either the visual or ROI approach. However in affected dogs, T2-weighted liver signal intensity was less than that of skeletal muscle by using either the ROI approach (10 of 10 dogs) or the visual approach (9 of 10 dogs). These findings suggest that the comparison of relative signal intensity among organs may have merit as a research model for infiltrative parenchymal disease (ROI approach) or metabolic effects of disease; this comparison may have practical clinical applicability (visual comparison approach) as well.

Document Type: Research Article

Affiliations: 1: Department of Veterinary Clinical Sciences, University of Minnesota, St Paul, Minnesota, USA. feene001@umn.edu 2: Department of Veterinary Clinical Sciences, University of Minnesota, St Paul, Minnesota, USA; The Masonic Cancer Center, University of Minnesota, St Paul, Minnesota, USA 3: Veterinary Medical Center, University of Minnesota, St Paul, Minnesota, USA 4: Department of Veterinary Clinical Sciences, University of Minnesota, St Paul, Minnesota. USA 5: Department of Veterinary Population Medicine, University of Minnesota, St Paul, Minnesota, USA 6: Department of Veterinary Clinical Sciences, University of Minnesota, St Paul, Minnesota, USA 7: Department of Veterinary Clinical Sciences, University of Minnesota, St Paul, Minnesota, The Masonic Cancer Center, USA

Publication date: April 1, 2013

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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