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Open Access Excision of Femoral Head and Neck for Treatment of Coxofemoral Degenerative Joint Disease in a Rhesus Macaque (Macaca mulatta)

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Nonhuman primates are a valuable model for osteoarthritis. Osteoarthritis has been extensively studied in nonhuman primates in both naturally occurring and induced disease states. However, little published information describes naturally occurring osteoarthritis of the coxofemoral joints of nonhuman primates. We report a case of naturally occurring coxofemoral joint osteoarthritis in a rhesus macaque. This case radiographically resembled hip dysplasia reported in other species and demonstrated a rapid progression in severity of lameness, with accompanying loss of muscle mass in the affected limb. We excised the femoral head and neck to alleviate the pain that accompanied the osteoarthritis. Physical therapy was initiated, and dual-energy X-ray absorptiometry and video recordings were performed to evaluate the macaque's response to surgical intervention. By 3 mo postoperatively, the macaque had regained full use of the affected limb.

Document Type: Case Report

Affiliations: 1: Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana, USA. jdufour@tulane.edu 2: Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana, USA 3: Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA 4: Department of Physiology and Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

Publication date: December 1, 2012

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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