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Open Access Complications of Elastase-Induced Arterial Saccular Aneurysm in Rabbits: Case Reports and Literature Review

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Endoluminal infusion and incubation of elastase with or without collagenase into the rabbit common carotid artery is an established model of arterial saccular aneurysm. The model mimics naturally occurring human cerebral aneurysms in many ways, including histologic and morphologic characteristics, hemodynamic pressures, and shear stresses. However, complications have been associated with the model. Here, we report 2 complications: 1) the first known case of iatrogenic laryngeal hemiplegia in a rabbit; and 2) histopathologically confirmed iatrogenic hippocampal and cerebellar infarcts (stroke). Finally, we present and review data from current literature on the morbidity and mortality associated with this model.
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Document Type: Research Article

Affiliations: 1: Department of Comparative Medicine, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA; Animal Resources Center, University of Texas Medical Branch, Galveston, Texas, USA. [email protected] 2: Department of Comparative Medicine, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA; Laboratory Animal Resource Center, Indiana University, Indianapolis, Indiana, USA 3: Department of Comparative Medicine, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA; York Veterinary Housecalls, York, Pennsylvania, USA 4: Department of Comparative Medicine, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA

Publication date: 2012-12-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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