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Open Access Acute Portal Hypertension Models in Dogs: Low- and High-Flow Approaches

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Abstract:

Effective animal models are needed to evaluate the feasibility of new techniques to assess portal hypertension (PH). Here we developed 2 canine models of acute PH by increasing intrasinusoidal resistance and by increasing the portal vein (PV) flow volume to test the efficacy of a noninvasive technique to evaluate PH. The acute low-flow PH model was based on embolization of liver circulation by using a gelatin sponge material. The acute high-flow PH model was based on increasing the PV flow volume by using an arteriovenous (A-V) shunt from the femoral artery and saline infusion. PV pressures and diameters were assessed before and after inducing PH. Pressure values and diameters were obtained from the inferior vena cava in 3 unmanipulated controls. The low-flow model of PH was repeatable and successfully increased PV pressure by an average of 16.5 mm Hg within 15 min. The high-flow model of PH failed to achieve increased PV pressures. However, saline supplementation of the portal circulation in the high-flow model led to mean increases in PV pressures of 12.8 mm Hg within 20 min. Pulsatility in the PV was decreased in the low-flow model and increased in the high-flow model relative to baseline. No changes in PV diameter were noted in either model. These acute PH models are relatively straightforward to implement and may facilitate the evaluation of new techniques to assess PH.

Document Type: Research Article

Affiliations: 1: Department of Radiology, Thomas Jefferson, Philadelphia, Pennsylvania, USA 2: Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA 3: Office of Animal Resources, Thomas Jefferson University, Philadelphia, Pennsylvania, USA 4: Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania 5: Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. flemming.forsberg@jefferson.edu

Publication date: 2012-10-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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