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Open Access High Incidence of Scrotal Hernias in a Closed Colony of FVB Mice

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Although inguinal hernias are rarely reported to occur in mice, a high incidence of scrotal hernias was observed in a closed breeding colony of FVB/N mice. Unilateral or bilateral hernias occurred in more than 20% of the male mice in the colony that were available for necropsy over 3 inbred and 1 outcross generations; no female mice were affected. Organs commonly present within the hernial sac included the cecum and seminal vesicles. Hernias did not adversely affect the fertility or lifespan of the affected male mice. Although the condition was heritable, no clear pattern of transmission was evident.

Document Type: Case Report

Affiliations: 1: Department of Molecular Carcinogenesis, Science Park, University of Texas MD Anderson Cancer Center, Smithville, Texas, USA 2: Department of Molecular Carcinogenesis, Science Park, University of Texas MD Anderson Cancer Center, Smithville, Texas, USA.

Publication date: October 1, 2012

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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