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Open Access Variation in CCL3L1 Copy Number in Rhesus Macaques (Macaca mulatta)

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Abstract:

We used real-time quantitative PCR (qPCR) methodology to examine copy number variation (CNV) of the CCL3L1 gene among pure Indian-origin, pure Chinese-origin, and hybrid Indian–Chinese rhesus macaques (Macaca mulatta). CNV among purebred macaques fell within expected ranges, with Indian macaques having lower copy numbers than those of Chinese macaques. Compared with the purebred macaques, Indian–Chinese hybrid rhesus macaques showed much greater variance in copy number and an intermediate average copy number. Copy numbers of CCL3L1 in rhesus macaque trios (sire, dam, and offspring) were consistent with Mendelian inheritance.

Document Type: Research Article

Affiliations: 1: Forensic Science Graduate Program, University of California, Davis, California, USA 2: Molecular Anthropology Laboratory, University of California, Davis, California, USA 3: Forensic Science Graduate Program, University of California, Davis, California, USA; Molecular Anthropology Laboratory, University of California, Davis, California; California National Primate Research Center, University of California, Davis, California, USA 4: Forensic Science Graduate Program, University of California, Davis, California, USA; Molecular Anthropology Laboratory, University of California, Davis, California, USA; California National Primate Research Center, University of California, Davis, California, USA; Department of Environmental Toxicology, University of California, Davis, California, USA

Publication date: 2012-06-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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