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Open Access Ulcerative Dermatitis in C57BL/6 Mice Exhibits an Oxidative Stress Response Consistent with Normal Wound Healing

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Abstract:

Ulcerative dermatitis (UD) is a common syndrome of unknown etiology that results in profound morbidity in C57BL/6 mice and lines on a C57BL/6 background. The lesions are due to severe pruritus-induced self-trauma, progressing from superficial excoriations to deep ulcerations. UD may be behavioral in origin, with ulcerative lesions resulting from self-mutilating behavior in response to unresolved inflammation or compulsion. Alternatively, abnormal oxidative damage may be a mechanism underlying UD. To evaluate whether UD behaves similarly to normal wounds, consistent with a secondary self-inflicted lesion, or is a distinct disorder with abnormal wound response, we evaluated expression levels of genes representing various arms of the oxidative stress response pathway UD-affected and unwounded C57BL/6J mice. No evidence indicated that UD wounds have a defect in the oxidative stress response. Our findings are consistent with an understanding of C57BL/6 UD lesions as typical rather than atypical wounds.

Document Type: Research Article

Affiliations: 1: Division of Laboratory Animal Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA 2: Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA 3: Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA; Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA; Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, USA

Publication date: 2012-06-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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