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Open Access Polyostotic Fibrous Dysplasia in a Cynomolgus Macaque (Macaca fascicularis)

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Abstract:

A 2.3-y-old female cynomolgus macaque (Macaca fascicularis) presented with a broken right tibia and fibula. Radiographs showed multiple cyst-like defects in all long bones. We suspected that both fractures were pathologic because they occurred through these defects. Ultrasonography, MRI, and dual X-ray absorptiometry revealed that the defects were filled with soft tissue. Grossly, the bones were abnormal in shape, and a gelatinous material filled the defects and the surrounding marrow cavity. Histologically, the gelatinous material was composed of fibrin and cartilage; few normal bone cells were seen. Genetic testing revealed extra material on the short arm of chromosome 8 in all tissues examined, but no copy number alterations of likely clinical significance were observed, and no abnormalities were found that were unique to the lesions. In light of the clinical signs and radiographic and pathologic findings, polyostotic fibrous dysplasia was diagnosed. This report represents the first documented case of fibrous dysplasia in a cynomolgus macaque.

Document Type: Case Report

Affiliations: 1: Southwest National Primate Research Center, University of Texas Health Science Center at San Antonio, USA. cbauer@txbiomed.org 2: Department of Clinical Laboratory Sciences, University of Texas Health Science Center at San Antonio, USA 3: Department of Pediatrics, Human Genetics, and Pathology and ARUP Laboratories, University of Utah School of Medicine, Salt Lake City, Utah, USA 4: Southwest National Primate Research Center, University of Texas Health Science Center at San Antonio, USA 5: Veterinary Diagnostic Pathology Service, Joint Pathology Center, Silver Spring, Maryland, USA 6: Department of Veterinary Imaging Center of South Texas, USA 7: Southwest National Primate Research Center, University of Texas Health Science Center at San Antonio, USA; Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, , USA; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA

Publication date: April 1, 2012

More about this publication?
  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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