@article {Zhou:2010:1532-0820:436,
	author = "Zhou, Jian and Luan, Guo-Dong and Ren, Lei-Ming and Wu, Zhi-Gang and Wang, Xue and Zhao, Yan",
	title = "Pharmacologic Characteristics of Bladder Micturition Function in Anesthetized Mice",
	journal = "Comparative Medicine",
	volume = "60",
	number = "6",
	year = "2010",
	abstract = "In the present study, we observed the effects of an &#945;<SUB>1</SUB>-adrenoceptor agonist (phenylephrine), &#946;-adrenoceptor agonist (isoprenaline), muscarinic cholinoceptor agonist (carbachol), and &#945;<SUB>1</SUB>-adrenoceptor antagonist (doxazosin) on the bladder micturition function in anesthetized mice. Changes in bladder pressure in response to filling and blood pressure were recorded by using a data acquisition system. Phenylephrine (50 to 800 &#956;g/kg) increased vesical micturition pressure in a dose-dependent manner but increased micturition basal pressure only at 800 &#956;g/kg. Carbachol (3 to 7 &#956;g/kg) increased the intercontraction interval and micturition time in a dose-dependent manner but increased micturition basal pressure only at 7 &#956;g/kg. Isoprenaline (10 to 1000 &#956;g/kg) increased micturition time and decreased vesical micturition pressure in a dose-dependent manner. Doxazosin (10 to 1000 &#956;g/kg) did not affect bladder micturition function but dose-dependently inhibited phenylephrine-induced increases in vesical micturition pressure. Carbachol (7 &#956;g/kg) and isoprenaline (1 mg/kg) caused a transient fall in blood pressure, whereas doxazosin (1 mg/kg) had a long-lasting hypotensive effect. The maximal decrease in systolic and mean blood pressure by carbachol did not differ from that by doxazosin and isoprenaline, respectively. Phenylephrine (800 &#956;g/kg) transiently increased the blood pressure of anesthetized mice. These results indicate that activation of muscarinic cholinoceptors decreases voiding frequency and increases bladder capacity in anesthetized mice. Activation of &#945;<SUB>1</SUB>-adrenoceptors mainly increases vesical micturition pressure, whereas activation of &#946;-adrenoceptors decreases vesical micturition pressure and prolongs micturition time in anesthetized mice.",
	pages = "436-442",
	url = "http://www.ingentaconnect.com/content/aalas/cm/2010/00000060/00000006/art00003"
}