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Open Access Pharmacologic Characteristics of Bladder Micturition Function in Anesthetized Mice

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Abstract:

In the present study, we observed the effects of an α1-adrenoceptor agonist (phenylephrine), -adrenoceptor agonist (isoprenaline), muscarinic cholinoceptor agonist (carbachol), and α1-adrenoceptor antagonist (doxazosin) on the bladder micturition function in anesthetized mice. Changes in bladder pressure in response to filling and blood pressure were recorded by using a data acquisition system. Phenylephrine (50 to 800 g/kg) increased vesical micturition pressure in a dose-dependent manner but increased micturition basal pressure only at 800 g/kg. Carbachol (3 to 7 g/kg) increased the intercontraction interval and micturition time in a dose-dependent manner but increased micturition basal pressure only at 7 g/kg. Isoprenaline (10 to 1000 g/kg) increased micturition time and decreased vesical micturition pressure in a dose-dependent manner. Doxazosin (10 to 1000 g/kg) did not affect bladder micturition function but dose-dependently inhibited phenylephrine-induced increases in vesical micturition pressure. Carbachol (7 g/kg) and isoprenaline (1 mg/kg) caused a transient fall in blood pressure, whereas doxazosin (1 mg/kg) had a long-lasting hypotensive effect. The maximal decrease in systolic and mean blood pressure by carbachol did not differ from that by doxazosin and isoprenaline, respectively. Phenylephrine (800 g/kg) transiently increased the blood pressure of anesthetized mice. These results indicate that activation of muscarinic cholinoceptors decreases voiding frequency and increases bladder capacity in anesthetized mice. Activation of α1-adrenoceptors mainly increases vesical micturition pressure, whereas activation of -adrenoceptors decreases vesical micturition pressure and prolongs micturition time in anesthetized mice.

Document Type: Research Article

Affiliations: Department of Pharmacology, School of Pharmacy Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China

Publication date: December 1, 2010

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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