Radiographic Incidence of Spinal Osteopathologies in Captive Rhesus Monkeys (Macaca mulatta)
Abstract:Degenerative spinal disease is a leading cause of chronic disability both in humans and animals. Although widely seen as a normal occurrence of aging, degenerative spinal disease can be caused by various genetic, iatrogenic, inflammatory, and congenital factors. The objective of this study was to characterize the degenerative spine-related diseases and the age at onset in a random subpopulation of 20 captive rhesus monkeys (Macaca mulatta; male, 13; female, 7; age: range, 4 to 27 y; median, 18.5 y). Spinal radiographic evaluation (left lateral, right lateral, and ventrodorsal views) of the spinal column (C1 to S1) was performed, and spinal degenerative disease was scored. The incidence of osteopathology was higher in the 14- to 18-y-old group, but incidence did not differ according to sex. In the studied population, degenerative changes were present in monkeys as young as 9 y of age.
Document Type: Research Article
Affiliations: 1: Nonhuman Primates Unit, Proyecto CAMINA A.C., Mexico City, México; Vertebrate Integral Biology (BioInvert): Animal Research Unit, State of Mexico, México. email@example.com firstname.lastname@example.org 2: Nonhuman Primates Unit, Proyecto CAMINA A.C., Mexico City, México; Vertebrate Integral Biology (BioInvert): Animal Research Unit, State of Mexico, México 3: Imaging, General Dr Manuel 'Gea' González SS Hospital, Mexico City, México 4: Investigational Units, General Dr Manuel 'Gea' González SS Hospital, Mexico City, México 5: Nonhuman Primates Unit, Proyecto CAMINA A.C., Mexico City, México 6: Ethology, Wildlife, and Laboratory Animals Department, School of Veterinary Medicine and Zootechnics, Universidad Nacional Autónoma de México, Mexico City, México
Publication date: 2010-10-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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