Morphometric Comparison of the Lumbar Cancellous Bone of Sheep, Deer, and Humans
Abstract:To investigate the feasibility of using deer and sheep as animal models for the human spine, we compared the microarchitectural dimensions of the deer and sheep spines and with human data. To this end, we adopted the traditional bone tissue morphometric method, using figure analysis software for quantitative analysis of 2D images of bone tissue. Compared with those of humans, the lumbar cancellous bone of deer and sheep has higher microarchitectural indices, more densely packed bone trabeculae, lower porosity, and higher bone mass. Despite specific differences in various morphologic indices, the anisotropy of lumbar cancellous bone in deer and sheep shows the same trend as that in humans.
Document Type: Research Article
Affiliations: 1: Department of Anatomy, Norman Bethune Medical School, Jilin University, Department of hand surgery, the First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China 2: Department of spine, the First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China 3: Department of Anatomy, Norman Bethune Medical School, Jilin University, Changchun, Jilin Province, China 4: Department of Anatomy, Norman Bethune Medical School, Jilin University, Changchun, Jilin Province, China. firstname.lastname@example.org
Publication date: 2010-10-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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