Open Access Animal Models of Substance Abuse and Addiction: Implications for Science, Animal Welfare, and Society

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Abstract:

Substance abuse and addiction are well recognized public health concerns, with 2 NIH institutes (the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism) specifically targeting this societal problem. As such, this is an important area of research for which animal experiments play a critical role. This overview presents the importance of substance abuse and addiction in society; reviews the development and refinement of animal models that address crucial areas of biology, pathophysiology, clinical treatments, and drug screening for abuse liability; and discusses some of the unique veterinary, husbandry, and IACUC challenges associated with these models.

Document Type: Research Article

Affiliations: 1: Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 2: Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 3: Division of Animal Resources, Virginia Commonwealth University, Richmond, Virginia 4: Office of Animal Welfare, University of Virginia, Charlottesville, Virginia. Email: plf6z@virginia.edu

Publication date: June 1, 2010

More about this publication?
  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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