Simian Betaretrovirus Infection in a Colony of Cynomolgus Monkeys (Macaca fascicularis)
Abstract:Of the 419 laboratory-bred cynomolgus macaques (Macaca fascicularis) in a breeding colony at our institution, 397 (95%) exhibited antibodies or viral RNA (or both) specific for simian betaretrovirus (SRV) in plasma. Pregnant monkeys (n= 95) and their offspring were tested to evaluate maternal–infant infection with SRV. At parturition, the first group of pregnant monkeys (n = 76) was antibody-positive but RNA-negative, the second group (n = 14 monkeys) was positive for both antibody and RNA, and the last group (n = 5) was antibody-negative but RNA-positive. None of the offspring delivered from the 76 antibody-positive/RNA-negative mothers exhibited viremia at birth. Eight of the offspring (including two newborns delivered by caesarian section) from the 14 dually positive mothers exhibited SRV viremia, whereas the remaining 6 newborns from this group were not viremic. All of the offspring (including 2 newborns delivered by caesarian section) of the 5 antibody-negative/RNA-positive mothers exhibited viremia at birth. One neonatal monkey delivered by CS and two naturally delivered monkeys that were viremic at birth remained viremic at 1 to 6 mo of age and lacked SRV antibodies at weaning. Family analysis of 2 viremic mothers revealed that all 7 of their offspring exhibited SRV viremia, 6 of which were also antibody-negative. The present study demonstrates the occurrence of transplacental infection of SRV in viremic dams and infection of SRV in utero to induce immune tolerance in infant monkeys.
Document Type: Research Article
Affiliations: 1: The Corporation for Production and Research of Laboratory Primates, National Institute of Biomedical Innovation, Tsukuba, Japan; Tsukuba Primate Research Center (TPRC), National Institute of Biomedical Innovation, Tsukuba, Japan. firstname.lastname@example.org 2: The Corporation for Production and Research of Laboratory Primates, National Institute of Biomedical Innovation, Tsukuba, Japan; Tsukuba Primate Research Center (TPRC), National Institute of Biomedical Innovation, Tsukuba, Japan 3: The Corporation for Production and Research of Laboratory Primates, Tsukuba, Japan 4: Tsukuba Primate Research Center (TPRC), National Institute of Biomedical Innovation, Tsukuba, Japan
Publication date: February 1, 2010
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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