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Open Access Infection of Cesarean-Derived Colostrum-Deprived Pigs with Porcine Circovirus Type 2 and Swine Influenza Virus

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Porcine circovirus type 2 (PCV2) and swine influenza virus (SIV) are important pathogens for porcine respiratory disease complex, which is economically significant worldwide. The pathogenesis of PCV2–SIV coinfection is unknown. In this study, we focused on establishing a challenge model for PCV2 to determine whether SIV influences PCV2 replication and increases the severity of PCV2-associated disease. Cesarean-derived colostrum-deprived pigs were inoculated intratracheally with cell culture medium only (negative control group), PCV2 only, or PCV2 followed 1 wk later with SIV H1N1. Two pigs from each group were necropsied at 12, 21, 28, and 35 d after inoculation. Coinfection with SIV did not increase the number of PCV2 genomic copies in serum or target tissues or the severity of microscopic lesions associated with PCV2 in lung or lymph node. The antibody titer to PCV2 did not differ significantly between PCV2–SIV- and PCV2-infected groups. In conclusion, SIV H1N1 did not influence PCV2 replication in dually infected pigs in this study.

Document Type: Research Article

Affiliations: 1: Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, USA 2: Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana 3: Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, Department of Veterinary Diagnostic and Production Medicine, Iowa State University, Ames, Iowa 4: Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, Diagnostic Center for Population and Animal Health, Michigan State University, Lansing, Michigan 5: Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, USA. rmp@purdue.edu

Publication date: February 1, 2010

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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