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Open Access Acute Phase Response in Animals: A Review

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Abstract:

The acute phase response is a complex systemic early-defense system activated by trauma, infection, stress, neoplasia, and inflammation. Although nonspecific, it serves as a core of the innate immune response involving physical and molecular barriers and responses that serve to prevent infection, clear potential pathogens, initiate inflammatory processes, and contribute to resolution and the healing process. Acute phase proteins, an integral part of the acute phase response, have been a focus of many applications in human diagnostic medicine and recently have been identified in common animal species. Potential applications to diagnosis, prognosis, assessment of animal health, and laboratory animal welfare are readily apparent.

Document Type: Research Article

Affiliations: 1: Division of Comparative Pathology, University of Miami Miller School of Medicine, Miami, Florida, USA. c.cray@miami.edu 2: Division of Comparative Pathology, Division of Veterinary Resources, University of Miami Miller School of Medicine, Miami, Florida 3: Division of Comparative Pathology, University of Miami Miller School of Medicine, Miami, Florida

Publication date: 2009-12-01

More about this publication?
  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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