Effect of Inositol Hexaphosphate on the Development of UVB-Induced Skin Tumors in SKH1 Hairless Mice
Abstract:Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is abundant in many plants and in various high-fiber foods, such as cereals and legumes. IP6 has a striking, broad-spectrum anticancer activity in various in vitro and animal models, in which it interferes with key pathways in malignancy to inhibit cell proliferation, cell-cycle progression, metastasis, invasion, and angiogenesis and to induce apoptosis. In this study, we investigated the protective effects of IP6 in drinking water on the incidence of UVB-induced skin cancer in the SKH1 (Crl: SKH1-hr) mouse model. One group of 15 mice received 2% IP6 in drinking water and UVB exposure, and the other group (n = 15) received UVB exposure only. All mice in both groups were fed an IP6-deficient diet (AIN 76A). The treatment group started receiving 2% IP6 in the drinking water 3 d before irradiation. Mice were irradiated 3 times each week, starting at a dose of 1.5 kJ/m2, with weekly increases in increments of 1.5 kJ/m2 to a final dose of 7.5 kJ/m2. Tumor formation was monitored until the week 31. IP6 in drinking water significantly decreased tumor incidence by 5-fold and tumor multiplicity by 4-fold. These results show that IP6 has an antiphotocarcinogenic effect and can protect against UVB-induced tumor formation.
Document Type: Research Article
Affiliations: 1: Program of Comparative Medicine, Departments of Pathology, Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 2: Department of Medical Research and Technology, University of Maryland School of Medicine, Baltimore, Maryland 3: Department of Veterinary Public Health and Animal Pathology, University of Bologna, Bologna, Italy 4: Program of Comparative Medicine, University of Maryland School of Medicine, Baltimore, Maryland 5: Departments of Pathology, Medical Research and Technology, University of Maryland School of Medicine, Baltimore, Maryland 6: Program of Comparative Medicine, Departments of Pathology, Epidemiology and Preventive Medicine, Medicine (Division of Infectious Diseases), University of Maryland School of Medicine, Baltimore, Maryland, USA. DeTolla@vetmed.umaryland.edu
Publication date: 2009-04-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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