Rat Prostate Tumors Express Cancer Procoagulant, an Activator of Coagulation Factor X
Authors: Kamocka, Malgorzata; Pollard, Morris; Suckow, Mark; Mielicki, Wojciech P; Rosen, Elliot D
Source: Comparative Medicine, Volume 58, Number 3, June 2008 , pp. 282-286(5)
Abstract:Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund–Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund–Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.
Document Type: Research Article
Publication date: June 1, 2008
- Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
Attention Members: To access the full text of the articles, be sure you are logged in to the AALAS website.
Attention: please note, due to a temporary technical problem, reference linking within the content is not available at this time
- Editorial Board
- Information for Authors
- Submit a Paper
- Subscribe to this Title
- Membership Information
- Information for Advertisers
- For issues prior to 1998
- Institutional Subscription Activation
- ingentaconnect is not responsible for the content or availability of external websites