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Open Access Simian Parvoviruses: Biology and Implications for Research

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The simian parvoviruses (SPVs) are in the genus Erythrovirus in the family Parvoviridae and are most closely related to the human virus B19. SPV has been identified in cynomolgus, rhesus, and pigtailed macaques. All of the primate erythroviruses have a predilection for erythroid precursors. Infection, which is common in macaques, is usually clinically silent. Disease from SPV is associated with immunosuppression due to infection with various retroviruses (SIV, simian retrovirus, and simian–human immunodeficiency virus), surgery, drug toxicity studies, and posttransplantation immunosuppressive treatment and therefore is of concern in studies that use parvovirus-positive macaques.

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Document Type: Research Article

Affiliations: Charles River Laboratories, Wilmington, MA, USA. [email protected]

Publication date: 2008-02-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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